How your skin and ECS works with CBD.



We addressed the internal workings of the endocannabinoid system in a previous article. We discovered that in the brain, nervous system, and immune system, we have cannabinoid receptors. The presence of these cannabinoid receptors partly explains why it can be helpful to supplement our routine with cannabinoids including CBD.

The value of applying cannabinoids externally is what was not addressed in our previous blog post. Cannabinoids don't penetrate the bloodstream when applied topically. This can leave concerns as to how CBD topics can be helpful. We'll address the role of the endocannabinoid system in the skin in this blog.


The Skin – Very complex and the body’s largest organ

How your skin and ECS works with CBD

We must first study the skin's functions in order to better understand the ECS and skin. The skin is a complex organ, in addition to serving as a defensive shield against the environment. It is a hormone source, has an immune system of its own and contains an abundance of sensory nerves.

Three layers make up the skin. The epidermis, which is formed by layers of cells called keratinocytes, is the outermost layer. The epidermis is waterproof and protects against environmental factors, such as UV radiation, bacteria, high temperatures, toxins, and allergens.

The next layer of skin, the dermis, is made of fibers of collagen and elastin that provide strength and elasticity to the skin. The dermis comprises many appendages: hair-producing follicles, sebum-providing sebaceous glands, and sweat-secreting glands. These appendages help to strengthen the waterproof barrier of the skin, regulate the temperature of the body, and produce hormones like steroids and vitamin D.

In the dermis, the skin's immune system is housed. Within this layer of skin, various immune cells reside or enter the skin when danger is present. Both skin cell types assist the immune system in defending and repairing the skin when appropriate.

How your skin and ECS works with CBD

A thick network of nerve fibers that recognize several stimuli is also present in the dermis. The skin is considered the largest sensory organ for this purpose.

Subcutis, which contains fat that serves as a fuel reserve, insulation, and cushion, is the final layer of the skin.


The ECS and Skin

The presence of the endocannabinoid system in the skin has been found in recent studies. The main aim of the ECS in the skin is to retain the balance between the roles of skin cells, such as reproduction, differentiation and immune competence.

Several cell types synthesize or produce endocannabinoids such as anandamide and 2-AG in the epidermis, hair follicles, and sebaceous glands. These compounds bind to the two main receptors for cannabinoids, CB1 and CB2, which are present in almost all skin cells.

Endocannabinoids, due to the strong involvement of cannabinoid receptors, influence all skin components and lead to their proper functioning. The skin is a complex organ that performs protection, immunity, and sensory functions, as discussed earlier. The list below describes the effects on the skin of the ECS.

Epidermis: Endocannabinoids stimulate cannabinoid receptors on epidermal cells to help control the protective barrier of the epidermis as well as suppress epidermal inflammation.

Immune Cells: The ECS regulates the function of the immune and inflammatory system of the skin. Endocannabinoids have anti-inflammatory properties and, when necessary, the ECS only stimulates the immune system.

Sebaceous Glands: A safe amount of cannabinoids contributes to sebaceous glands functioning properly. It leads to healthy skin when the glands secrete sufficient amounts of sebum containing lipids.

Sensory Nerves: On sensory nerve endings, cannabinoid receptors are found. The receptors can block the action of the structures when triggered. This can inhibit pain and suppress itchy feelings.


How CBD Works Topically

The skin relies on the role of skin cell homeostasis. Much as taking CBD internally helps to preserve homeostasis, the balance of skin cell activity is topically regulated by administering CBD. Cannabinoids complement and imitate the function of the endocannabinoids that are produced in the skin. In different clinical conditions, CBD interacts with the cannabinoid receptors in the skin and displays promise. We urge you to explore the many skin benefits of CBD.

How your skin and ECS works with CBD

CBD topicals are used by many for muscle and joint relief. Those with localized problems, such as knees, hands, and feet, find useful subjects. We hold a line of CBD salves, lotions, pads, and facial treatment at CBD Nirvana.

Topical CBD balm  VS Transdermal CBD Products

It is possible to divide CBD products for skin into 2 main categories. Topical and transdermal.

CBD products from Trandsdermal are goods that pass through the skin barrier and into the blood stream.

Topical CBD oil is intended to interact with the endocannabinoid system receptor points of the top layer of the skin (epidermis) (see image below). The CBD oil does not, thus, move into the blood stream and operates in the skin instead.

Image Courtesy of

How to apply CBD Oil on Skin

CBD Patch

Inflamed or dry skin, in particular, might reap many benefits from CBD oil. A CBD Patch, which can be left for 12 hours on the skin, is the most convenient method. Patches take away the challenge of re-applying CBD oil during the day, but they target a particular area.

Topical issues effecting a larger area can be better served with a  CBD rub-on cream.


Learning the role of the endocannabinoid system in the skin helps us understand how our skin benefits from CBD. Do you have additional ECS and skin questions? Leave a comment below!

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